San Pellegrino is produced and bottled at San Pellegrino, Terme, in the Province of Bergamo, Lombardy, Italy.  The water may originate from a layer of rock 400 metres (1,300 ft.) below the surface, where it is mineralized from contact with limestone and volcanic rocks. It emerges from three deep springs at a temperature of about 22°C (72°F).

The springs are located at the foot of a Dolomite mountain wall which favours the formation and replenishment of a mineral water basin. The water then seeps to depths of over 700 m (2,300 ft.) and flows underground to a distant aquifer.